VIP-helodermin receptors in the murine virus-induced t lymphoma cell line BL/VL3 recover less rapidly than βadrenoceptors after down regulation

C. Damien; P. Robberecht; J. Abello; R. Hooghe; J. Christophe

doi:10.3109/10799898909066069

VIP-helodermin receptors in the murine virus-induced t lymphoma cell line BL/VL₃ recover less rapidly than βadrenoceptors after down regulation

C. Damien
, P. Robberecht
, J. Abello
, R. Hooghe
, J. Christophe

Research output › peer-review

Abstract

The time course of recovery of βadrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL₃, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of βadrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: βadrenoceptors recovered faster than VIP/helodermin receptors.

Original language	English
Pages (from-to)	441-449
Number of pages	9
Journal	Journal of Receptors and Signal Transduction
Volume	9
Issue number	6
DOIs	https://doi.org/10.3109/10799898909066069
State	Published - 1989

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.3109/10799898909066069

Cite this

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title = "VIP-helodermin receptors in the murine virus-induced t lymphoma cell line BL/VL3 recover less rapidly than βadrenoceptors after down regulation",

abstract = "The time course of recovery of βadrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of βadrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: βadrenoceptors recovered faster than VIP/helodermin receptors.",

author = "C. Damien and P. Robberecht and J. Abello and R. Hooghe and J. Christophe",

year = "1989",

doi = "10.3109/10799898909066069",

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journal = "Journal of Receptors and Signal Transduction",

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T1 - VIP-helodermin receptors in the murine virus-induced t lymphoma cell line BL/VL3 recover less rapidly than βadrenoceptors after down regulation

AU - Damien, C.

AU - Robberecht, P.

AU - Abello, J.

AU - Hooghe, R.

AU - Christophe, J.

PY - 1989

Y1 - 1989

N2 - The time course of recovery of βadrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of βadrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: βadrenoceptors recovered faster than VIP/helodermin receptors.

AB - The time course of recovery of βadrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of βadrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: βadrenoceptors recovered faster than VIP/helodermin receptors.

UR - https://www.scopus.com/pages/publications/0024957272

U2 - 10.3109/10799898909066069

DO - 10.3109/10799898909066069

M3 - Article

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AN - SCOPUS:0024957272

SN - 1079-9893

VL - 9

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EP - 449

JO - Journal of Receptors and Signal Transduction

JF - Journal of Receptors and Signal Transduction

IS - 6

ER -