Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization

Sarah Baatout, Franco Cortese, Dmitry Klokov, Andreyan Osipov, Jakub Stefaniak, Marjan Moreels, Alexey Moskalev, Jane Schastnaya, Charles Cantor, Alexander Aliper, Polina Mamoshina, Igor Ushakov, Alex Sapetsky, Quentin Vanhaelen, Irina Alchinova, Mikhail Karganov, Olga Kovalchuk, Ruth Wilkins, Andrey Shtemberg, Evgeny IzumchenkoJoão Pedro de Magalhães, Artem V. Artemov, Sylvain Costes, Afshin Beheshti, Xiao Wen Mao, Michael Pecaut, Dmitry Kaminskiy, Ivan Ozerov, Morten S Scheibye-Knudsen, Alex Zhavoronkov

    Research outputpeer-review


    While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.
    Original languageEnglish
    Number of pages30
    JournalOncotarget - Impact Journals
    VolumeAdvance Publications 2018
    StatePublished - 6 Mar 2018

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