What can biofabrication do for space and what can space do for biofabrication

Lorenzo Moroni, Kevin Tabury, Hilde Stenuit, Daniela Grimm, Sarah Baatout, Vladimir Mironov

    Research outputpeer-review


    Biofabrication in space is one of the novel promising and prospective researchdirections in the rapidly emergingfield of space STEM. There are several advan-tages of biofabrication in space. Under microgravity, it is possible to engineerconstructs using morefluidic channels and thus more biocompatible bioinks.Microgravity enables biofabrication of tissue and organ constructs of more complexgeometries, thus facilitating novel scaffold-, label-, and nozzle-free technologiesbased on multi-levitation principles. However, when exposed to microgravity andcosmic radiation, biofabricated tissues could be used to study pathophysiologicalphenomena that will be useful on Earth and for deep space manned missions.Here, we provide leading concepts about the potential mutual benefits of the appli-cation of biofabrication technologies in space.
    Original languageEnglish
    Pages (from-to)398-411
    Number of pages14
    JournalTrends in Biotechnology
    Issue number4
    StatePublished - Apr 2022

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